S-Adenosylmethionine: A Novel Factor in the Individualization of Thiopurine Therapy
نویسندگان
چکیده
Individualizing drug therapy by the use of pharmacogenomics offers the opportunity to improve drug efficacy, reduce adverse side effects, and provide cost-effective pharmaceutical care. 6-mercaptopurine (6-MP), 6-thioguanine (6-TG) and azathioprine (AZA) are widely prescribed cytotoxic and immunosuppressive drugs used in the therapy of acute leukaemia, inflammatory bowel diseases, allograft rejections and others.
منابع مشابه
Pharmacogenetics of thiopurine therapy: from thiopurine S-methyltransferase to S-adenosylmethionine
Background The efficiency and safety of the thiopurine therapy rely on the concentration of patient's cytotoxic thioguanine nucleotides (TGN), which in turn depend on the deactivation of thiopurine drugs by thiopurine S-methyltransferase (TPMT). The activity of TPMT largely depends on the presence of genetic polymorphisms. Determination of mutations in the TPMT gene before starting 6-mercaptopu...
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Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme, catalyzing S-methylation of thiopurine drugs. TPMT exhibits autosomal codominant polymorphism. Patients carrying a variant genotype have low TPMT activity, and produce elevated levels of 6-thioguanine nucleotides (6-TGN) in their red blood cells (RBC). 6-TGN accumulation may result in azathioprine (AZA)-induced bone marrow myelosuppre...
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